工程力学系
办公电话：34207804
电子邮件：x.gong@sjtu.edu.cn
通讯地址：木兰楼A811室
澳门太阳网城官网工程力学系教授、博士生导师；上海交通大学数字医学临床转化教育部工程研究中心兼职教授；上海交通大学生命学院高峰学科跨学科人才项目兼职教授。工程力学系副主任（科研、国际合作）。上海市浦江人才。日本理化学研究所客座研究员。
现任中国力学学会和中国生物医学工程学会生物力学专业委员会委员，上海市生物物理学会常务理事，上海市力学学会生物力学专业委员会副主任，日本理化学研究所客座研究员。《Frontiers in Physiology》、《Journal of Hydrodynamics》、《水动力学研究与进展》、《医用生物力学》、《力学季刊》杂志编委。
于西安交通大学获得学士和博士学位；历任东京大学JSPS博士后、东京大学工学部智能模拟室助理研究员、日本理化学研究所研究员（Research Scientist），2009年回国，历任上海交通大学工程力学系副教授、特别研究员、博士生导师、教授。
研究方向包括：细胞尺度生物流体力学、柔性微流控芯片创新、和细胞力学与人体疾病。主要致力于面向生命的力学与多学科交叉创新。依托上海交大力学系、医学院和生命学院开展基础性、前瞻性的实验创新和计算机仿真研究。
主持国家重点研发计划1项、国家自然科学基金面上项目4项，上海市浦江人才计划，教育部博士点基金等各1项。在国际顶级期刊PNAS，Journal of Fluid Mechanics，Lab on a Chip, Journal of Computational Physics等发表SCI论文60余篇。
①. 微流控芯片技术及其在临床检测和治疗中的应用
*循环肿瘤细胞、胎儿有核红细胞等临床高价值稀有细胞的全血物理分离及其应用
*单细胞力学特性的高通量测量技术开发及其在人体慢病监测中的应用
*单细胞传质机理研究及其在癌症免疫治疗中的应用
②. 柔性可穿戴传感器创新
*基于柔性微管技术的可穿戴传感器和柔性触觉传感器开发及其应用
③. 流固耦合数值分析
*面向细胞尺度血流动力学和传质的复杂数值模拟方法研究及应用
*热烈欢迎力学、机械、动力工程、应用数学或统计、生物医学工程背景学生报考硕士、博士研究生。欢迎本科生加入实验室开展PRP和大学生创新项目实践。
*实验室与MIT、东京大学、新加坡国立大学等世界一流大学相关领域实验室有着实质性的学术交流合作。
*实验室长期招聘微流控芯片技术、流体-结构耦合数值分析、可穿戴传感器领域的博士后。根据上海交通大学的有关政策为优秀博士后提供有竞争力的薪资待遇。博士后出站可竞聘上海交大长聘教轨系列职位。
学会任职
2021年至今 《Mechanobiology in Medicine》编委
2020年至今 《力学季刊》编委
2016年至今 中国力学学会/中国生物医学工程学会 生物力学专业委员会委员
2012年至今 上海市生物物理学会 理事/常务理事(2015~)
2016年至今 《Journal of Hydrodynamics》、《水动力学研究与进展》 编委
2014年至今 《医用生物力学》 编委
2009-2012、2019-2021 日本理化学研究所 客座研究员
2009年至今 中国生物医学工程学会 高级会员
2020年至今 中国力学学会高级会员
学术会议任职
2021年10月 第三届国际长三角力生物学研讨会暨第九届全国医学生物物理学术会议 大会主席
2018年8月 第十二届全国生物力学学术会议暨第十四届全国生物流变学学术会议 学术委员会委员
2017年11月 International workshop on Molecular, Cell and Tissue Mechanobiology 大会共同主席
2015年8月 中国力学大会 学术委员会委员
作为PI负责：
2020 国家自然科学基金面上项目 （12072198）
2019 国家重点研发计划政府间国际科技创新合作重点专项（2017YFE0117100）
2018 国家自然科学基金面上项目 （11872040）
2014 国家自然科学基金面上项目 （11372191）
2013 国家留学基金委海外访问项目
2011 国家自然科学基金面上项目（11072155）
2010 教育部博士点基金新教师项目
2010 教育部留学归国人员基金项目
2009 上海市浦江人才项目
参与项目：
2018 MIT Greater China Fund
2013 国家自然科学基金重点项目
Selected Journal papers
Wei QD, Xiong Y., Ma YH, Liu DY, Lu YS, Zhang SH., Wang XL., Huang HX, Liu YB., Dao M.*, Gong XB.*, High-throughput single-cell assay for precise measurement of the intrinsic mechanical properties and shape charachteristics of red blood cells, Lab on a Chip, 24, 305-316, 2024
Chao Wang, Jingjing Ding, Qiaodong Wei, Shoukang Du, Xiaobo Gong, Ting Gang Chew*, Mechanosensitive accumulation of non-muscle myosin IIB during mitosis requires its translocation activity, iScience, 26: 107773, 2023
Qiaodong Wei, Xiaolong Wang, Ce Zheng, Ming Dao, Xiaobo Gong*, Evolution of surface area and membrane shear modulus of matured human red blood cells during mechanical fatigue, Scientific Reports, 13:8563, 2023
Wang XL, Ii S., Sugiyama K., Noda S., Jing P., Liu DY, Che XJ, Gong XB*, Effect of mechanical properties of red blood cells on their equilibrium states in microchannels, Physics of Fluids, 2023 (Featured Article), doi.org/10.1063/5.0141811
Shenbao Chen, Jingchen Zhu, Jian Xue, Xiaolong Wang, Peng Jing, Luwen Zhou, Yuhong Cui, Tianhao Wang, Xiaobo Gong*, Shouqin Lu*, Mian Long*, Numerical simulation of flow characteristics in a permeable liver sinusoid with leukocytes, Biophysical Journal, 2022, https://doi.org/10.1016/j.bpj.2022.10.022
Peng Jing, Satoshi Ii, Xiaolong Wang, Kazuyasu Sugiyama, Shigeho Noda, Xiaobo Gong*, Effects of fluid-cell-vessel interactions on the membrane tensions of circulating tumor cells in capillary blood flows, Physics of Fluids, 34, 031904, 2022 (Featured Article)
Xinyue Liu, Keni-chi Tsubota, Yi Yu, Wang Xi, Xiaobo Gong*, A numerical method to predict the membrane tension distribution of spreading cells based on the reconstruction of focal adhesions, Science China: Physics, Mechanics & Astronomy, 65(6): 264612, 2022
Xiao‑Ming Zhang, Ying‑Hong Tao, Xiu‑Ling Zhou, Xi‑Liang Shang, Xiao‑Bo Gong, Ying‑Chao Liu, Yan‑Yan Huang, Gang Chen, Zhong‑Yu Yu, Jian‑Tao Wang, Zun‑Guo Du, Guo‑Feng Wu, Yu Zhang, Jing‑Chun Guo, Hou‑Guang Zhou*, The role of carbonic anhydrase III and autophagy in type 2 diabetes with cardio-cerebrovascular disease, Metabolic Brain Disease, 36:2329–2341, 2021
Yi Yu, Liujie Ren, Xinyue Liu, Xiaobo Gong, Wei Yao, Effects of substrate stiffness on mast cell migration, European Journal of Cell Biology, 100:151178, 2021
Han Bao, Zi-Tong Li, Lei-Han Xu, Tong-Yue Su, Yue Han, Min Bao, Ze Liu, Yang-Jing Fan, Yue Lou, Yi Chen, Zong-Lai Jiang, Xiao-Bo Gong, Ying-Xin Qi*, Platelet-derived extracellular vesicles increase Col8a1 secretion and vascular stiffness in intimal injury, Frontiers in Cell and Developmental Biology, 9: 641763, 2021
Xiaolong Wang, Xiaobo Gong*, Kazuyasu Sugiyama, Shu Takagi, Huaxiong Huang*, An immersed boundary method for mass transfer through porous biomembranes under large deformations, Journal of Computational Physics, 413:109444, 2020 DOI: 10.1016/j.jcp.2020.109444
Shuo Wang, Xuejin Li*, Xiaobo Gong, Haojun Liang, Mechanistic modeling of spontaneous penetration of carbon nanocones into membrane vesicles， Nanoscale, 12:2686, 2020 DOI: 10.1039/c9nr09098c
Shaoxiong Yang, Xiaobo Gong*, Yingxin Qi, Zonglai Jiang, Comparative study of variations in mechanical stress and strain of human blood vessels: mechanical reference for vascular cell mechano-biology, Biomechanics and Modeling in Mechanobiology, 19:519-531, 2020 DOI 10.1007/s10237-019-01226-1
Shaoxiong Yang, Qinghu Wang, Weihao Shi, Wencheng Guo, Zonglai Jiang, Xiaobo Gong*, Numerical study of biomechanical characteristics of plaque rupture at stenosed carotid bifurcation: a stenosis mechanical property-specific guide for blood pressure control in daily activities, Acta Mechanica Sinica 35: 1279–1289, 2019
Shaoxiong Yang, Yingxin Qi, Zonglai Jiang, Xiaobo Gong*, Characterizing the mechanical variations of human femoropopliteal artery during aging process, Molecular & Cellular Biomechanics, 16(1)：13-26, 2019
Xinyue Liu, Hongwei Yang, Yunqiao Liu, Xiaobo Gong*, Huaxiong Huang, Numerical study of clathrin-mediated endocytosis of nanoparticles by cells under tension, Acta Mechanica Sinica, 35(3): 691-701, 2019
Qian Xiao, Xia Tang, Yuanxiu Chen, Han Bao, Lizhi Gao, Xiaobo Gong*, Ping Zhang*, Oct-1 mediates ACTH-induced proliferation of vascular smooth muscle cells, Molecular & Cellular Biomechanics, 16(3): 199-210, 2019
Shaoxiong Yang, Xiaobo Gong*, Yingxin Qi, Zonglai Jiang, An analytical investigation of in vivo mechanical references for mechanobiological experiments of vascular cells, Molecular & Cellular Biomechanics, 16 (Supplemental 1): 9-10, 2019
Peng Jing, Xiaolong Wang, Shigeho Noda, Xiaobo Gong*, Numerical analysis of motion and stress distribution of circulating tumor cells in micro vessels, Molecular & Cellular Biomechanics, 16(Suppl.2): 36-37, 2019
Xinyue Liu, Yunqiao Liu, Xiaobo Gong*, Huaxiong Huang，A numerical study of passive receptor-mediated endocytosis of nanoparticles: the effect of mechanical properties, Computer Modeling in Engineering & Sciences, 116 (2): 281-300, 2018
Hongwei Yang, Xinyue Liu, Zhoufeng Shen, Wei Yao*, Xiaobo Gong*, Huaxiong Huang, Guanghong Ding, An investigation of the distribution and location of mast cells affected by the stiffness of substrates as a mechanical niche, International Journal of Biological Sciences, 14(9): 1142-1152, 2018 (Co-corresponding authors)
Khateeb Noor Ul Huda, Kazuya Shimizu, Xiaobo Gong, Shu Takagi*, Numerical investigation of COD reduction in compact bioreactor with bubble plumes, Chemical Engineering Science, 185:1-17, 2018
Shaoxiong Yang, Lucy T. Zhang, Cheng Hua, Yunqiao Liu, Jingdong Tang, Xiaobo Gong*, Zonglai Jiang, A prediction of in vivo mechanical stresses in blood vessels using thermal expansion method and its application to hypertension and vascular stenosis, Acta Mechanica Sinica, 34, 6：1156–1166, 2018 （Best Paper Awards）
Yunqiao Liu, Dongdong He, Xiaobo Gong*, Huaxiong Huang, Deformation of an encapsulated bubble in steady and oscillatory electric fields, Journal of Fluid Mechanics, 844:567-596, 2018
Wang Xi, Fang Kong, Joo Chuan Yeo, Longteng Yu, Surabhi Sonam, Ming Dao, Xiaobo Gong*, and Chwee Teck Lim*, Soft tubular microfluidics for 2D and 3D applications, Proceedings of the National Academy of Sciences of the United States of America, 114(40):10590-10595, 2017 (co-corresponding authors)
Wang GL, Wang LY, Yang SX, Chen XH, Yao QP, Gong XB, Qi YX, Jiang ZL, Han HC, Rat arterial wall remodeling under sustained twist. Journal of Biomechanics, 60:124-133, 2017
Xiaobo Gong, Zhaoxin Gong, Huaxiong Huang*, An immersed boundary method for mass transfer across permeable moving interfaces, Journal of Computational Physics, 278: 148-168, 2014
Jing Xu, Xiaolong Wang, Yunqiao Liu, Xiaobo Gong*, A Cellular scale numerical study of the effect of mechanical properties of erythrocytes on the near-wall motion of platelet, Acta Mechanica Sinica, 30 (2): 274-280, 2014
Z. Yan, Y. Li, B. Cheng, Q. Yao, L. Gao, Q. Gao. X. Gong, Y. Qi*, Z. Jiang Effects of stretched vascular endothelial cells and smooth muscle cells on differentiation of endothelial progenitor cells, Journal of Mechanics in Medicine and Biology, 13(2):1350050, 2013
Satoshi Ii*, Xiaobo Gong, Kazuyasu Sugiyama, Jinbiao Wu,Huaxiong Huang, Shu Takagi, A full Eulerian fluid-membrane coupling method with a smoothed volume-of-fluid approach, Communications in Computational Physics, 12(2): 544-576, 2012
Gong XB*, Li YQ, Gao QC, Chen BB, Shen BR, Yan ZQ, Jiang ZL, Adhesion behavior of endothelial progenitor cells to endothelial cells in simple shear flows, Acta Mechanica Sinica, 27(6): 1071-1080, 2011
Xiaobo Gong, Kazuyasu Sugiyama, Shu Takagi*, Yoichiro Matsumoto The deformation behavior of multiple red blood cells in a capillary vessel, ASME Journal of Biomechanical Engineering, 131: 074504, 2009
Shu Takagi*, Takeshi Yamada, Xiaobo Gong, Yoichiro Matsumoto, 2009, The deformation of a vesicle in a linear shear flow, Journal of Applied Mechanics, 76, 021207
Xiaobo Gong, Shu Takagi*, Yoichiro Matsumoto, 2009, The effect of bubble-induced liquid flow on mass transfer in bubble plumes, International Journal of Multiphase Flow, 35, 155-162
Xiaobo Gong*, Shu Takagi, Huaxiong Huang, Yoichiro Matsumoto, 2007, A numerical study of mass transfer of ozone dissolution in bubble plumes with a Euler-Lagrange Method, Chemical Engineering Science, 62(4), 1081-1093
Invited Talks:
1) 人体血管在体应力的数值重建及其应用，2019年中国力学大会生物力学分会场，邀请报告，杭州，2019
2) Soft tubular microfluidics for particle sorting and wearable sensors, 2018年中国生物医学工程学会天津青年论坛，特邀报告，天津，2018
3) Xiaobo Gong*, Satoshi Ii, Kazuyasu Sugiyama, Huaxiong Huang, Shu Takagi, 2011, Approaching Cell Mechanics by Numerical Simulations Based on Continuum Mechanical Method, Mini-symposium of the 11th US National Congress on Computational Mechanics, Minneapolis, USA 2011, No.219489
4) Xiaobo Gong*, Huaxiong Huang, 2011, A Numerical Study on the Mass Transfer over Cell Membranes Based on Immersed Boundary Method, Mini-symposium: Multiscale modelling of Cellular Mechanobiology & Cell Mechanics, the 5th Shanghai International Conference on Biophysics and Molecular biology, Nov 4~8 Shanghai, China
本科生课程：
《工程流体力学》工科大平台（48学时）
《细胞工程力学》致远学院交叉课程(48学时)
《细胞工程力学》力学强基前沿课程 (16学时)
研究生课程：
《生物流体力学》
授权专利：
龚晓波, 一种稀有细胞和颗粒富集分离柔性微管流控芯片, 中国，ZL201710670356.X
龚晓波，张晟泓，魏桥栋，一种热聚合物微管的制备装置，中国，ZL202022280669.4
龚晓波，刘洁，张晟泓，基于微管流控芯片的细胞捕获方法，中国，ZL202110041651.5
XI Wang, LIM Chwee Teck, KONG Fang, GONG Xiaobo, Versatile flexible and biocompatible elastomeric microtubes, PCT/US 2017/151915 A1，美国，11161736B2
シー，ワン；リム，チュウィー，テック；コン，ファン；ゴン，シアオボー，汎用、可撓性かつ生体適合性エラストマーマイクロチューブ，日本，7041878
Acta Mechanica Sinica 2020 Best Paper Wards，2020
上海市浦江人才，2009年9月，上海市科委
上海交通大学教书育人集体二等奖，2019年9月，排名第十，上海交通大学
Professor Huaxiong Huang@York Univ Huaxiong Huang - Faculty of Science Profiles (yorku.ca)
Professor Chew Teck Lim@NUS MechanoBioEngineering Laboratory - People (ctlimlab.org)
Professor Shu Takagi@Univ Tokyo Shu TAKAGI's Home Page (u-tokyo.ac.jp)
Professor Kazuyasu Sugiyama@Osaka Univ Sugiyama Lab. (osaka-u.ac.jp)
Professor Yasuhiro Inoue@Kyoto Univ 井上 康博 (inoue-lab.info)
Dr. Ming Dao@MIT Ming Dao's Home Page (mit.edu)
Dr. Wang Xi@CNRS Cell Adhesion and Mechanics | Members (cnrs.fr)
